Rare Pulmonology News

Disease Profile

Apocrine carcinoma

Prevalence
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.

Unknown

Age of onset

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ICD-10

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Inheritance

Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease

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Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype

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X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.

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X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder

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Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.

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Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.

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Not applicable

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Summary

Apocrine carcinoma is a cancer of a sweat gland. Apocrine carcionoma most often develops under the arm (the axilla), but it can develop on the scalp or other parts of the body.[1][2] The cause of apocrine carcinoma is unknown. Apocrine carcinoma usually appears as a single, small, painless bump (nodule) that can vary in color and slowly increases in size.[1][2] The average age at the time of diagnosis is 62 years of age, and twice as many men are affected than women.[2] Most apocrine carcinomas can be treated and are not fatal.[2][3] Treatment of apocrine carcinoma is surgery to remove as much of the cancer as possible.[1][2][3] Additional treatments such as radiation therapy and chemotherapy have been used to treat this condition, but the usefulness of these treatments is unproven.[3]

Learn more

These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

In-Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.

References

  1. Miyamoto T, Hagari Y, Inoue S, Watanabe T, Yoshino T. Axillary apocrine carcinoma with benign apocrine tumours: a case report involving a pathological and immunohistochemical study and review of the literature. Journal of Clinical Pathology. 2005; 58(7):757-761. https://www.ncbi.nlm.nih.gov/pubmed/15976347. Accessed 6/16/2014.
  2. Katagiri Y, Ansai S.. Two cases of cutaneous apocrine ductal carcinoma of the axilla. Case report and review of the literature. Dermatology. 1999; 199(4):332-337. https://www.ncbi.nlm.nih.gov/pubmed/10640844. Accessed 6/16/2014.
  3. Vucinic I, Stojadinovic T, Mikez ZB, Danic D, Coha B.. Apocrine carcinoma of the scalp with aggressive clinical course--a case report and review of the literature. Collegium Antropologicum. 2012; 36:209-212. https://www.ncbi.nlm.nih.gov/pubmed/23397789. Accessed 6/16/2014.