Rare Pulmonology News

Disease Profile

Brucellosis

Prevalence
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.

Unknown

Age of onset

All ages

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ICD-10

A23.0 A23.1 A23.2 A23.3 A23.8 A23.9

Inheritance

Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease

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Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype

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X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.

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X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder

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Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.

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Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.

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Not applicable

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Other names (AKA)

Malta fever; Undulant fever; Rock fever;

Categories

Bacterial infections

Summary

Brucellosis is a bacterial infection that spreads from animals to people via unpasteurized dairy products or by exposure to contaminated animal products or infected animals.[1][2] Animals that are most commonly infected include sheep, cattle, goats, pigs, and dogs. Brucellosis can cause of range of signs and symptoms, some of which may persist or recur. Initial symptoms may include fever, sweats, malaise, anorexia, headache, fatigue, and/or pain in the muscles, joints, and/or back. Symptoms that may persist or recur include fevers, arthritis, swelling of the testicle and scrotum, swelling of the heart (endocarditis), neurologic symptoms (in up to 5% of cases), chronic fatigue, depression, and/or swelling of the liver or spleen. People who are in jobs or settings that increase exposure to the bacteria are at increased risk for infection. Antibiotics are used to treat brucellosis.[1] Recovery may take a few weeks to several months, and relapses are common.[1][2] Death from brucellosis is rare, occurring in no more than 2% of cases.[1]

Symptoms

This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.

Medical Terms Other Names
Learn More:
HPO ID
30%-79% of people have these symptoms
Abnormality of hepatobiliary system physiology
0025155
Abnormality of the gastrointestinal tract
0011024
Anemia
Low number of red blood cells or hemoglobin
0001903
Anorexia
0002039
Arthralgia
Joint pain
0002829
Asthenia
0025406
Elevated C-reactive protein level
0011227
Elevated erythrocyte sedimentation rate
High ESR
0003565
Fatigue
Tired
Tiredness

[ more ]

0012378
Fever
0001945
Hepatomegaly
Enlarged liver
0002240
Hyperhidrosis
Excessive sweating
Increased sweating
Profuse sweating
Sweating
Sweating profusely
Sweating, increased

[ more ]

0000975
Increased circulating IgG level
0003237
Leukopenia
Decreased blood leukocyte number
Low white blood cell count

[ more ]

0001882
Nausea
0002018
Septic arthritis
0003095
Splenomegaly
Increased spleen size
0001744
Weight loss
0001824
5%-29% of people have these symptoms
Abdominal pain
Pain in stomach
Stomach pain

[ more ]

0002027
Abnormality of bone marrow cell morphology
0005561
Abnormality of the peripheral nervous system
0410008
Bronchitis
0012387
Chills
0025143
Cutaneous cyst
0025245
Depressivity
Depression
0000716
Epididymitis
0000031
Erythematous papule
0030350
Failure to thrive
Faltering weight
Weight faltering

[ more ]

0001508
Glomerulonephritis
0000099
Granuloma
0032252
Headache
Headaches
0002315
Hip osteoarthritis
0008843
Hypersplenism
0001971
Immunologic hypersensitivity
0100326
Increased circulating IgM level
0003496
Knee osteoarthritis
0005086
Leukocytosis
Elevated white blood count
High white blood count
Increased blood leukocyte number

[ more ]

0001974
Liver abscess
0100523
Lymphadenopathy
Swollen lymph nodes
0002716
Orchitis
Inflammation of testicles
0100796
Osteomyelitis
Bone infection
0002754
Peripheral neuropathy
0009830
Pleural effusion
Fluid around lungs
0002202
Pneumonia
0002090
Premature birth
Premature delivery of affected infants
Preterm delivery

[ more ]

0001622
Purpura
Red or purple spots on the skin
0000979
Rheumatoid factor positive
0002923
Sacroiliac arthritis
0012317
Small for gestational age
Birth weight less than 10th percentile
Low birth weight

[ more ]

0001518
Spontaneous abortion
0005268
Thrombocytopenia
Low platelet count
0001873
Vomiting
Throwing up
0002013
1%-4% of people have these symptoms
Abnormal aortic valve morphology
0001646
Abnormal cranial nerve physiology
0031910
Anterior uveitis
0012122
Arteritis
Inflammation of artery
0012089
Chorea
0002072
Chorioretinitis
0012424
Encephalitis
Brain inflammation
0002383
Endocarditis
0100584
Intrarenal abscess
0032620
Lung abscess
0025044
Myocarditis
Inflammation of heart muscle
0012819
Pericarditis
Swelling or irritation of membrane around heart
0001701
Pulmonary granulomatosis
0030250
Thrombocytosis
Increased number of platelets in blood
0001894
Thrombophlebitis
0004418
Transient ischemic attack
Mini stroke
0002326
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References

  1. Brucellosis. Centers for Disease Control and Prevention. November 12, 2012; https://www.cdc.gov/brucellosis/. Accessed 12/12/2014.
  2. Brucellosis. Mayo Clinic. January 2, 2014; https://www.mayoclinic.org/diseases-conditions/brucellosis/basics/definition/con-20028263. Accessed 12/12/2014.
  3. Wafa Al-Nassir. Brucellosis. Medscape Reference. March 10, 2014; https://emedicine.medscape.com/article/213430-overview. Accessed 12/12/2014.

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