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Disease Profile
Juvenile dermatomyositis
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
Unknown
Age of onset
Infancy
ICD-10
M33.0
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Juvenile DM
Categories
Kidney and Urinary Diseases; Lung Diseases; Musculoskeletal Diseases;
Summary
Juvenile dermatomyositis has some similarities to adult dermatomyositis and polymyositis. It typically affects children ages 2 to 15 years, with symptoms that include weakness of the muscles close to the trunk of the body, inflammation, edema, muscle pain, fatigue, skin rashes, abdominal pain, fever, and
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
80%-99% of people have these symptoms | ||
Autoimmunity |
Autoimmune disease
Autoimmune disorder
[ more ] |
0002960 |
Calcinosis |
Calcium buildup in soft tissues of body
|
0003761 |
Dry skin | 0000958 | |
Elevated C-reactive |
0011227 | |
Elevated |
High ESR
|
0003565 |
Elevated serum creatine kinase |
Elevated blood creatine phosphokinase
Elevated circulating creatine phosphokinase
Elevated creatine kinase
Elevated serum CPK
Elevated serum creatine phosphokinase
High serum creatine kinase
Increased CPK
Increased creatine kinase
Increased creatine phosphokinase
Increased serum CK
Increased serum creatine kinase
Increased serum creatine phosphokinase
[ more ] |
0003236 |
Erythema | 0010783 | |
Fatigue |
Tired
Tiredness
[ more ] |
0012378 |
Mucosal telangiectasiae | 0100579 | |
Muscle weakness |
Muscular weakness
|
0001324 |
Myalgia |
Muscle ache
Muscle pain
[ more ] |
0003326 |
Myositis |
Muscle inflammation
|
0100614 |
Palpebral edema |
Fullness of eyelids
Puffy eyelids
Puffy lids
Swelling of eyelids
[ more ] |
0100540 |
Skin rash | 0000988 | |
Telangiectasia of the skin | 0100585 | |
30%-79% of people have these symptoms | ||
Alopecia |
Hair loss
|
0001596 |
Arthralgia |
Joint pain
|
0002829 |
Joint inflammation
|
0001369 | |
Constipation | 0002019 | |
Cutaneous photosensitivity |
Photosensitive skin
Photosensitive skin rashes
Photosensitivity
Sensitivity to sunlight
Skin photosensitivity
Sun sensitivity
[ more ] |
0000992 |
Fever | 0001945 | |
Muscle spasm | 0003394 | |
Muscular |
Low or weak muscle tone
|
0001252 |
Poikiloderma | 0001029 | |
Pruritus |
Itching
Itchy skin
Skin itching
[ more ] |
0000989 |
Restrictive ventilatory defect |
Stiff lung or chest wall causing decreased lung volume
|
0002091 |
Skin ulcer |
Open skin sore
|
0200042 |
Vasculitis |
Inflammation of blood vessel
|
0002633 |
5%-29% of people have these symptoms | ||
Abdominal pain |
Pain in stomach
Stomach pain
[ more ] |
0002027 |
Angina pectoris | 0001681 | |
Arrhythmia |
Abnormal heart rate
Heart rhythm disorders
Irregular heart beat
Irregular heartbeat
[ more ] |
0011675 |
Bundle branch block | 0011710 | |
Disease of the heart muscle
|
0001638 | |
Cough |
Coughing
|
0012735 |
Difficulty articulating speech
|
0001260 | |
Poor swallowing
Swallowing difficulties
Swallowing difficulty
[ more ] |
0002015 | |
Dysphonia |
Inability to produce voice sounds
|
0001618 |
Dyspnea |
Trouble breathing
|
0002094 |
EMG abnormality | 0003457 | |
Gastrointestinal hemorrhage |
Gastrointestinal bleeding
|
0002239 |
Hoarse voice |
Hoarseness
Husky voice
[ more ] |
0001609 |
Limitation of joint mobility |
Decreased joint mobility
Decreased mobility of joints
Limited joint mobility
Limited joint motion
[ more ] |
0001376 |
Pericarditis |
Swelling or irritation of membrane around heart
|
0001701 |
Pulmonary fibrosis | 0002206 | |
Weight loss | 0001824 |
Related diseases
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
|
---|
Differential diagnosis in JDM may include mitochondrial myopathies, infectious myopathies, other forms of inflammatory myopathies, particularly autoimmune necrotizing myopathy (see this term), as well as Duchenne muscular dystrophy or Becker muscular dystrophy, systemic lupus erythematosus, and juvenile idiopathic arthritis (see these terms).
Visit the Orphanet disease page for more information.
|
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
-
Cure JM Foundation
P.O. Box 45768
Baltimore, MD 21297
Telephone: (760) 487-1079
E-mail: [email protected]
Website: https://www.curejm.org/ -
Myositis Support and Understanding
9125 N. Old State Road
Lincoln, DE 19960
Toll-free: 1-888-MYO-RARE (696-7273)
Telephone: +1-302-339-3241
E-mail: [email protected]
Website: https://understandingmyositis.org/ -
Myositis UK
146 Newtown Road
Woolston
Southampton
SO19 9HR
United Kingdom
Telephone: 023 8044 9708
E-mail: [email protected]
Website: https://www.myositis.org.uk/ -
The Myositis Association (TMA)
1940 Duke Street
Suite 200
Alexandria, VA 22314
Toll-free: 1-800-821-7356
Telephone: +1-703-299-4850
Fax: +1-703-535-6752
E-mail: [email protected]
Website: https://www.myositis.org/
Organizations Providing General Support
-
American Autoimmune Related Diseases Association (AARDA)
19176 Hall Road, Suite 130
Clinton Township, MI 48038
Toll-free: 800-598-4668
Telephone: 586-776-3900
Fax: 586-776-3903
E-mail: [email protected]
Website: https://www.aarda.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The Myositis Association provides basic information on juvenile myositis.
In-Depth Information
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Juvenile dermatomyositis. Click on the link to view a sample search on this topic.
References
- Inflammatory Myopathies Fact Sheet. National Institute of Neurological Disorders and Stroke (NINDS). July 27, 2015; https://www.ninds.nih.gov/disorders/inflammatory_myopathies/detail_inflammatory_myopathies.htm.
- Myositis: Treatment. The Myositis Association. March 2015; https://www.myositis.org/learn-about-myositis/treatment.